What is Rosiglitazone?

Rosiglitazone, which is sold under the brand name Avandia, is a diabetes medication prescribed to treat type 2 diabetes, also known as “adult-onset” diabetes or “non-insulin dependent” diabetes.

Rosiglitazone is an antidiabetic drug in the thiazolidinedione class of drugs. It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Rosiglitazone is a member of the thiazolidinedione class of diabetes drugs that work to reduce high blood sugar levels by increasing the body’s insulin sensitivity.Although Rosiglitazone may be used in combination with insulin or other medications, Rosiglitazone should not be taken by patients with Type 1 diabetes or patients who are less than 18 years old.

People with Type 2 diabetes have high blood sugar levels because their bodies do not respond to insulin, a hormone released by the pancreas that helps glucose move out of the blood and into the cells in the body, where the glucose can be used as energy and nourishment. Often referred to as an "insulin sensitizer," Rosiglitazone attaches to insulin receptors on cells throughout the body, causing the cells to become more responsive to insulin and thus absorb glucose from the blood stream. By reducing the amount of sugar in the bloodstream, Rosiglitazone may help people with diabetes avoid several health problems related to diabetes, such as:

• heart disease
• blindness
• kidney failure
• stroke

Rosiglitazone Safety Concerns

Recently, diabetes medications, such as Rosiglitazone, have been linked to various serious side effects, including swelling and weight gain that can lead to heart failure.. In fact, in a study published in September 2007, Rosiglitazone approximately doubled the risk of heart failure and increased the risk of heart attack by more than 40 percent. In rare cases, Rosiglitazone may also cause potentially life-threatening liver problems.

As early as September 2005, both Rosiglitazone and Pioglitazione have been suspected of causing Macular Edema, which causes partial blindness in various spots of the angle of vision. While blindness is also a possible effect of diabetes, which Rosiglitazone is intended to treat, an article in Canadian journal CMAJ has documented several occurrences and recommends discontinuation at the first sign of vision problems. Both TZD's are contraindicated in patients with NYHA Class III and IV heart failure.

Quick Facts about Rosiglitazione

Congestive heart failure occurs when the heart can no longer pump enough blood to maintain adequate circulation. Because the heart doesn't pump properly, fluid often builds up in the lungs.

More than 65 percent of deaths among diabetic patients are heart disease related. That is important issue for rosiglitazione lawyers.

Avandia has been shown in studies to increase the chance of heart attack by 43% and risk of cardiovascular death by 64%

Avandia was approved in 1999 for treatment of type 2 diabetes, a serious and life threatening disease that affects about 18 to 20 million Americans.

The medical term for heart attack is myocardial infarction. A heart attack is also sometimes called a coronary thrombosis or coronary occlusion.

On June 7, 2007 the FDA ordered a Black Box Warning. The "black box" warning is the strongest warning that the FDA adds to labels on medications that may pose a health threat to users.

So, there a lots of rosiglitazione lawyers a, please, fell free to contact them.

AVANDIA INCREASE THE RISK OF STROKE

Avandia has been shown in studies to increase the risk of stroke. About 700,000 Americans each year suffer a stroke, and there are different types. The ischemic type is caused by a blocked blood vessel and the intracerebral hemorrhagic (ICH) type is caused by a ruptured blood vessel. More than 65% of people with diabetes die from heart disease or stroke.

In April of 2007 the US Food and Drug Administration (FDA) approved safety labeling revisions to advise of the increased risk for cardiovascular events associated with use of rosiglitazone maleate tablets in patients with New York Heart Association class 1 and 2 cardiac status; the risks for stroke, and deep vein thrombosis.

Diabetic patients with a family history of heart disease, cardiovascular disease, stroke, or congestive heart failure have a higher risk of these conditions when taking Avandia than nondiabetic patients.

What is a stroke? Stroke is a type of cardiovascular disease. It affects the arteries leading to and within the brain. A stroke occurs when a blood vessel that carries oxygen and nutrients to the brain is either blocked by a clot or bursts. When that happens, part of the brain cannot get the blood (and oxygen) it needs, so it starts to die.

Avandia - Rosiglitazione – side effects

As with any medication, Rosiglitazione may cause side effects. The severity of Rosiglitazione side effects depends on several factors, including a patient’s medical history and over-all health. Although Rosiglitazione side effects can range from mild to life-threatening, most people who take Rosiglitazione only experience mild side effects, including:

• headache
• fatigue
• back pain
• gradual weight gain
• sneezing and runny nose
• mild diarrhea

Serious Side Effects Associated with Avandia

Recently, Avandia has been linked to several serious, and potentially life-threatening, side effects. One of those side effects is swelling and weight gain, which can lead to heart failure. In addition, studies on Avandia’s side effects have produced results suggesting that Avandia may increase the risk of heart attack. In fact, one particular study on Avandia side effects, which was published in 2007, found that Avandia approximately doubled the risk of heart failure and increased the risk of heart attack by more than 40 percent.

In rare cases, Rosiglitazione may also cause liver problems, which can be fatal. Rosiglitazione patients who experience side effects associated with liver complications should stop using Avandia and seek medical attention immediately. These side effects include:

• nausea
• vomiting
• lethargic feelings of no energy
• a loss of appetite
• dark urine
• Additionally, patients should stop using Rosiglitazione and call a doctor at once if they experience any of these serious side effects:
• feeling short of breath, even with mild exertion
• swelling or rapid weight gain
• chest pain or heavy feeling, pain spreading to the arm or shoulder, sweating, general ill feeling
• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stool, jaundice (yellowing of the skin or eyes)
• blurred vision
• increased thirst or hunger, urinating more than usual
• pale skin, easy bruising or bleeding, weakness

Rosiglitazione Lawyers – Here to help you

If you have made the decision to engage in legal action related to Avandia, you may be wondering what happens next. On this page you will find answers to your questions, and a summary of the steps that you will take when filing a Avandia – Rosiglitazione lawsuit. This is not an exhaustive description of all of the events and outcomes that could be a part of your Avandia litigation experience, but it will give you an idea of what to expect.

What Should I Do First in an Avandia Lawsuit?

Before you file a claim, before you contact the defendant, before you make any complaints or admissions, contact an attorney. Every step of your litigation process can be critical to the end result and you do not want to make any mistakes that will compromise your ability to obtain compensation you are due. An Avandia attorney will be an expert in the type of lawsuit you are filing and can guide you through the process in the most knowledgeable way possible. Fill out a contact form and submit it to LegalView to be referred to an Avandia lawyer in your city, state or region.

How Do I Begin the Avandia Litigation Process?

Step one in Avandia litigation is filing a complaint, also known as a cause of action. The cause of action states what your injuries are, the parties you believe to be responsible, how and why they are responsible, and what kind of reparations you are seeking. This cause of action must describe why the defendant in the claim is specifically responsible for your Avandia injury. It should also explain why the court with which you are filing is the appropriate court to hear the case.

How Do Avandia Lawsuit Trial Proceedings Work?

There Is a Standard Protocol For Court Trials

• Opening Statements
  Before any evidence, witnesses or examinations, each attorney is given time to make an opening statement. At this time, each side will state what they will attempt to prove during their presentation of their case.
• Plaintiff's Case
  As the plaintiff, you bear the burden of proof in your Avandia case. Therefore, your attorney will present your case first, including all of your evidence and witnesses. The defense attorney will cross-examine your witnesses at this time.
• Motion to Dismiss
  Before proceeding, the defense attorney will often request that the judge dismiss the case, stating that the plaintiff's attorney has not presented enough proof. This request is usually denied; if it is, and the trial will continue.
• Defendant's Case
  The defense will present their case second, attempting to disprove the claims made by the plaintiff's side. Your attorney will cross-examine any witnesses called by the defense at this time. When finished, the defense will rest its case.
• Rebuttal
  After the defense rests its case, the prosecution (your attorney) will be given the opportunity to rebut the claims made by the defense by submitting new evidence and testimonies that refute the defendant's claims.
• Closing Statements
  Both parties will be given the opportunity to summarize their case and make a final plea to the jury for an outcome in their favor.
• Jury Deliberation
  The jury will be taken to a separate area in the courthouse to discuss and consider the evidence and testimony presented during the case. They are asked to come to a conclusion based on the legally admissible evidence they have heard and seen, and to enter a verdict in favor of either the plaintiff or the defendant. The jury will remain in deliberation as long as it takes to reach a unanimous verdict. If they are unable to do so, they will be considered a "hung" or "deadlocked" jury. If this happens, the judge will declare a mistrial. In the event of a mistrial, the case may be retried, or the parties may decide to dismiss the case or settle out of court.
• Verdict
  When the jury re-enters the courtroom, the judge will read the verdict. Based on the verdict the court will then make a final ruling as to the amount of damages due to the winning party.

Avandia Lawsuits

Current Avandia Litigation & Class Action Lawsuits

Avandia Lawyers have filed a class-action shareholder lawsuit against GlaxoSmithKline alleging that the company failed to disclose the increased health risks that may be associated with its diabetes drug, Avandia. The lawsuit, which was filed in June 2007 in a New York federal court, also names GlaxoSmithKline’s CEO and CFO as defendants.

GlaxoSmithKline’s stock fell sharply in 2007 after the New England Journal of Medicine published study findings suggesting that Avandia increases the risk of heart attacks.

According to the lawsuit, GlaxoSmithKline itself had already compiled a similar analysis that also found that Avandia increases the risk of heart attacks. The company, which did not widely publicize this finding, claims it found the analysis unpersuasive, given the fact that several other studies failed to show a significant increase in heart attack risk. Nevertheless, the lawsuit argues that the GlaxoSmithKline top officers artificially inflated

GlaxoSmithKline’s stock price by failing to adequately disclose the study findings which revealed the potentially dangerous effects of Avandia.

Avandia Personal Injury Lawsuits

If you or a family member has used the prescription drug Avandia and experienced adverse side effects, you may be entitled to compensation for your injuries. Our Avandia lawyers can help you seek compensation by filing a lawsuit on your behalf. With a lawsuit, our Avandia lawyers may help you get reimbursed for expenses such as medical bills, loss of income, and pain and suffering.

By seeking assistance from our experienced Avandia lawyers, an Avandia victim can quickly determine whether they have grounds for a lawsuit. Moreover, our experienced Avandia lawyers can inform victims of their legal rights and options, as well as their chances at succeeding in a lawsuit. So far, Avandia lawyers have already helped several victims and their families file lawsuits seeking compensation for their injuries.

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